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29 October 2008 year (time zone GMT 00:00)  Number of sources in English: 4959
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Grrreat Numbers

29.10.2008 23:32    brandweek.com
Procter & Gamble, Kraft and Kellogg all reported higher-than-expected earnings after raising prices and putting ad dollars behind key brands.


Deferred Prosecution Agreement

29.10.2008 22:49    neuro-ortho.org
Last night while listening to Daniel Shorr's commentary on NPR, I was reminded that I have seen very little if any coverage in the Chicago media concerning the Deferred Prosecution Agreement (DPA) between the US Department of Justice and the

Stress - Guided Meditation Cds

29.10.2008 22:26    simplifyyourthoughts.com
Here, it is not at all any question of creed, or doctrine - even men who are very much opposed to all religious ideas, when they see one of these acts of complete self - sacrifice, feel that they must

Y chromosome evidence of earliest modern human settlement in East Asia and multiple origins of Tibetan and Japanese populations

29.10.2008 18:28    biomedcentral.com
Background:The phylogeography of the Y chromosome in Asia previously suggested that modern humans of African origin initially settled in mainland southern East Asia, and about 25,000-30,000 years ago, migrated northward, spreading throughout East Asia. However, the fragmented distribution of one


Heterogeneous in vitro effects of doxorubicin on gene expression in primary human liposarcoma cell lines

29.10.2008 18:28    biomedcentral.com
Background:Doxorubicin is considered one of the most potent established chemotherapeutics in the treatment of liposarcoma; however, the response rates usually below 30%, are still disappointing. This study was performed to identify gene expression changes in liposarcoma after doxorubicin treatment.Methods:Cells of

Bioequivalence study of three ibuprofen formulations after single dose administration in healthy volunteers

29.10.2008 18:28    biomedcentral.com
Background:This phase I study was designed to determine the bioavailability and bioequivalence of 400 mg Eudorlin(R) extra (Ibuprofen) in comparison to two reference formulations (400 mg Nurofen(R) forte and 400 mg Migranin(R)) after single dose administration under fasting conditions in

Anatomical variation of co-existence of 4th and 5th short metacarpal bones, sesamoid ossicles and exostoses of ulna and radius in the same hand: a case report

29.10.2008 18:28    biomedcentral.com
IntroductionThe anatomical variations of bones in the hand are common. The existence of exostosis and shortening of metacarpal bones has been described in the literature as part of the hereditary multiple exostosis syndrome but no case has been reported with

A highly sensitive, PCR-based method for the detection of Plasmodium falciparum clones in microtiter plates

29.10.2008 18:28    biomedcentral.com
Background:Cloning of parasites by limiting dilution is an essential and rate-limiting step in many aspects of malaria research including genomic and genetic manipulation studies. The standard Giemsa-stained blood smears to detect parasites is time-consuming, whereas the more sensitive parasite lactate

Simultaneous feature selection and parameter optimisation using an artificial ant colony: case study of melting point prediction

29.10.2008 18:28    biomedcentral.com
Background:We present a novel feature selection algorithm, Winnowing Artificial Ant Colony (WAAC), that performs simultaneous feature selection and model parameter optimisation for the development of predictive quantitative structure-property relationship (QSPR) models. The WAAC algorithm is an extension of the modified

Computational cluster validation for microarray data analysis: experimental assessment of Clest, Consensus Clustering, Figure of Merit, Gap Statistics and Model Explorer

29.10.2008 18:28    biomedcentral.com
Background:Inferring cluster structure in microarray datasets is a fundamental task for the so-called -omic sciences. It is also a fundamental question in Statistics, Data Analysis and Classification, in particular with regard to the prediction of the number of clusters in

Mercury immune toxicity in harbour seals: links to in vitro toxicity

29.10.2008 18:28    biomedcentral.com
Background:Mercury is known to bioaccumulate and to magnify in marine mammals, which is a cause of great concern in terms of their general health. In particular, the immune system is known to be susceptible to long-term mercury exposure. The aims

A general SNP-based molecular barcode for Plasmodium falciparum identification and tracking

29.10.2008 18:28    biomedcentral.com
Background:Single nucleotide polymorphism (SNP) genotyping provides the means to develop a practical, rapid, inexpensive assay that will uniquely identify any Plasmodium falciparum parasite using a small amount of DNA. Such an assay could be used to distinguish recrudescence from re-infection

Influence of rub-in technique on required application time and hand coverage in hygienic hand disinfection

29.10.2008 18:28    biomedcentral.com
Background:Recent data indicate that full efficacy of a hand rub preparation for hygienic hand disinfection can be achieved within 15 seconds (s). However, the efficacy test used for the European Norm (EN) 1500 samples only the fingertips. Therefore, we investigated

Development of selective blockers for Ca2+-activated Cl- channel using Xenopus laevis oocytes with an improved drug screening strategy

29.10.2008 18:28    biomedcentral.com
Background:Ca2+-activated Cl- channels (CaCCs) participate in many important physiological processes. However, the lack of effective and selective blockers has hindered the study of these channels, mostly due to the lack of good assay system. Here, we have developed a reliable

The role of the t-SNARE SNAP-25 in action potential-dependent calcium signaling and expression in GABAergic and glutamatergic neurons

29.10.2008 18:28    biomedcentral.com
Background:The soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex, comprised of SNAP-25, syntaxin 1A, and VAMP-2, has been shown to be responsible for action potential (AP)-dependent, calcium-triggered release of several neurotransmitters. However, this basic fusogenic protein complex may be further

A novel asynchronous access method with binary interfaces

29.10.2008 18:28    biomedcentral.com
Background:Traditionally synchronous access strategies require users to comply with one or more time constraints in order to communicate intent with a binary human-machine interface (e.g., mechanical, gestural or neural switches). Asynchronous access methods are preferable, but have not been used

First-in-class, first-in-human phase I results of targeted agents: Highlights of the 2008 American Society of Clinical Oncology meeting

29.10.2008 18:28    biomedcentral.com
This review summarizes phase I trial results of 11 drugs presented at the American Society of Clinical Oncology meeting held in Chicago IL from May 30 to June 3rd 2008: BMS-663513, CT-322, CVX-045, GDC-0449, GRN163L, LY2181308, PF-00562271, RAV12, RTA 402,

Bartholin's abscess arising within hidradenoma papilliferum of the vulva: a case report

29.10.2008 18:28    biomedcentral.com
Background:Hidradenoma papilliferum is an uncommon, benign, cystic, papillary tumor that occurs almost exclusively in the female anogenital region. Bartholin's abscess is also an anogenital cystic lesion caused by obstruction of Bartholin's duct with an overlying infection. Concomitant presentation of Bartholin's

Integrating chromosomal aberrations and gene expression profiles to dissect rectal tumorigenesis

29.10.2008 18:28    biomedcentral.com
Background:Accurate staging of rectal tumors is essential for making the correct treatment choice. In a previous study, we found that loss of 17p, 18q and gain of 8q, 13q and 20q could distinguish adenoma from carcinoma tissue and that gain

Information-based methods for predicting gene function from systematic gene knock-downs

29.10.2008 18:28    biomedcentral.com
Background:The rapid annotation of genes on a genome-wide scale is now possible for several organisms using high-throughput RNA interference assays to knock down the expression of a specific gene. To date, dozens of RNA interference phenotypes have been recorded for

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